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Journal Article

Journal Article

Management of cerebral azole-resistant Aspergillus fumigatus infection: A role for intraventricular liposomal-amphotericin B  [2020]

A.F.A.D. Schauwvlieghe; R.G.M. Bredius; R.M. Verdijk; F.J.W. Smiers; et al.

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Objectives: In the pre-azole era, central nervous system (CNS) infections with Aspergillus had a dismal outcome. Survival improved with voriconazole but CNS infections caused by azole-resistant Aspergillus fumigatus preclude its use. Intravenous liposomal-amphotericin B (L-AmB) is the preferred treatment option for azole-resistant CNS infections but has suboptimal brain concentrations. Methods: We describe three patients with biopsy-proven CNS aspergillosis where intraventricular L-AmB was added to systemic therapy. Two patients with azole-resistant aspergillosis and one patient with azole-susceptible CNS aspergillosis were treated with intraventricular L-AmB at a dose of 1 mg weekly. Results: We describe three patients successfully treated with a combination of intravenous and intraventricular L-AmB. All three patients survived but one patient developed serious headaches, most likely not related to this treatment. Conclusions: Intraventricular L-AmB may have a role in the treatment of therapy-refractory CNS aspergillosis when added to systemic therapy.

Bibliographic information

Language:
English
Type:
Journal Article
In AGRIS since:
2022
Publisher:
Elsevier
All titles:
"Management of cerebral azole-resistant Aspergillus fumigatus infection: A role for intraventricular liposomal-amphotericin B"@eng
Other:
"Journal of Global Antimicrobial Resistance, Vol 22, Iss , Pp 354-357 (2020)"
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Bibliographic information

Language:
English
Type:
Journal Article
In AGRIS since:
2022
Publisher:
Elsevier
All titles:
"Management of cerebral azole-resistant Aspergillus fumigatus infection: A role for intraventricular liposomal-amphotericin B"@eng
Other:
"Journal of Global Antimicrobial Resistance, Vol 22, Iss , Pp 354-357 (2020)"