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Tsukuba Business-Academia Cooperation Support Center, Agriculture, Forestry and Fisheries Research Council Secretariat of the Ministry of Agriculture, Forestry and Fisheries, Japan (MAFF) was established in 1978 as Tsukuba Office and has been planning and operating various research facilities for supporting experimental research activities of research agencies, prefectural organizations and universities. The Tsukuba Business-Academia Cooperation Support Center is currently managing two centers, Agriculture, Forestry and Fisheries Research Infor [...]

Journal Article

Journal article

Study on anti-metastatic activity of a propolis constituent, CAPE, and its analogues  [2004]

Kadota, S. (Toyama Medical and Pharmaceutical Univ. (Japan)); Tezuka, Y.;

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Caffeic acid phenethyl ester (CAPE) and Its 20 analogues were tested by MTT assay on growth of six tumor cell lines, and found that CAPE analogues possess selective antiproliferative activity towards highly liver-metastatic murine colon 26-L5 carcinoma cell line. Then, the effects of CAPE analogues on the metastatic development of murine colon 26-L5 carcinoma cell in the lung were examined. The oral administration of CAPE (5 mg/mice/d) for 7 d after tumor inoculation decreased the tumor weight and the number of tumor nodules in the lung by 50% and 50%. respectively, compared to the control. Beside CAPE, 4-phenylbutyl caffeate, 8-phenyl-7-octenyl caffeate. 2 cyclohexylethyl caffeate, and n-octyl caffeate at an oral dose of 2 mg/mice/d caused a 55%. 43%. 55%. and 35% reduction of the tumor nodules in their lung metastasis formation, respectively. These results further elaborate the possibility of CAPE and its analogues to become a new class of chemopreventive agents for the treatment of colon cancer metastasis.

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Honeybee Science - Tamagawa University (Japan)

ISSN : 0388-2217