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Tsukuba Business-Academia Cooperation Support Center, Agriculture, Forestry and Fisheries Research Council Secretariat of the Ministry of Agriculture, Forestry and Fisheries, Japan (MAFF) was established in 1978 as Tsukuba Office and has been planning and operating various research facilities for supporting experimental research activities of research agencies, prefectural organizations and universities. The Tsukuba Business-Academia Cooperation Support Center is currently managing two centers, Agriculture, Forestry and Fisheries Research Infor [...]

Journal Article

Journal Article

Effects of du-zhong [Eucommia ulmoides] leaf extract on plasma and hepatic lipids in rats fed on a high fat plus high cholesterol diet  [1995]

Nakasa, T. (Doshisha Women's Univ., Kyoto (Japan)); Yamaguchi, M.; Okinaka, O.; Metori, K.; et al.

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Male Wistar rats were fed on a 1% cholesterol plus 12% lard containing-diet for 2 weeks (HC group). Accumulation of cholesterol and triacylglycerol was observed in their livers. The level of cholesterol in plasma of HC group was increased to 1.6 times that in the normal (Nor) group, while the level of triacylglycerol was lower than that in the Nor group. Plasma lipoproteins in the HC group were characterized by an increase in very low density lipoprotein (VLDL)-plus low density lipoprotein (LDL)-cholesterol level and a decrease in high density lipoprotein (HDL)-cholesterol level. Subsequently, the diet of the HC group was switched to a normal diet, and this group was divided into two groups of HCN and HCND. HCND group was orally administered Du-Zhong leaf extract, and HCN group was given tap water ad libitum. After feeding for two more weeks, the levels of plasma and hepatic cholesterol in the HCND group significantly decreased, and the level of hepatic triacylglycerol in this group was also lower than that in HCN group. The ratio of HDL-cholesterol to total cholesterol became greater by the administration of Du-Zhong leaf extract. On the other hand, the level of VLDL -+ LDL-cholesterol in HCND group was significantly lower than that in HCN group. While no difference of acetyl-CoA carboxylase activity in liver was observed among HCN, HCND, and Nor groups, the activity of fatty acid synthetase in HCND group was lower than that in the HCN group and was nearl
y equal to that in the Nor group. These results suggest that Du-Zhong leaf extract may have recuperative effects for hypercholesterolemia and fatty liver

From the journal

Journal of the Agricultural Chemical Society of Japan (Japan)
ISSN : 0002-1407

Bibliographic information

Language:
Japanese
Type:
Summary
In AGRIS since:
1997
Volume:
69
Issue:
11
Start Page:
1491
End Page:
1498
All titles:
"Effects of du-zhong [Eucommia ulmoides] leaf extract on plasma and hepatic lipids in rats fed on a high fat plus high cholesterol diet"@eng
Other:
"Summaries (En, Ja)"
"5 tables; 47 ref."
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Bibliographic information

Language:
Japanese
Type:
Summary
In AGRIS since:
1997
Volume:
69
Issue:
11
Start Page:
1491
End Page:
1498
All titles:
"Effects of du-zhong [Eucommia ulmoides] leaf extract on plasma and hepatic lipids in rats fed on a high fat plus high cholesterol diet"@eng
Other:
"Summaries (En, Ja)"
"5 tables; 47 ref."