AGRIS

Data provider:

Icon data provider

A Laboratory of Experimentation Research Institution and Provincial Rural Development Administration owns 70,000 of an Independent Volume and Periodical Publication. We provide literature information service througout Local Catss Library Official program which input upper information by internet.

Active (Data provider submitted metadata in the last calendar year)
Journal Article

Journal Article

A Rapid and Sensitive Screening System for Human Type Ⅰ Collagen with the Aim of Discovering Potent Anti-Aging or Anti-Fibrotic Compounds  [2008]

Abul Hashem, Md. (Ewha Womans University, Seoul, Republic of Korea); Jun, K.Y. (Ewha Womans University, Seoul, Republic of Korea); Lee, E.Y. (Ewha Womans University, Seoul, Republic of Korea); Lim, S.Y. (Ewha Womans University, Seoul, Republic of Korea); et al.

Access the full text

  • NOT AVAILABLE
This study was undertaken with the aim of developing an easy and quick means of analyzing the effect of various compounds on the synthesis and secretion of human type Ⅰ collagen at the protein level. A modification of the ELISA method was used on HFF-1 cells. For the proof of concept, we used thirteen compounds most of which are known to be antioxidants. Each compound was tested at concentrations of 0, 10 and 100 μM on HFF-1 cells for 24 h. Thirteen sets of experiments for each compound were performed in ANOVA with three replicates. Duncan multiple range test (DMRT) was used to compare the mean values obtained from the treatment groups. From the results it was concluded that Vitamin C, undecylenic acid, conjugated linoleic acid, glycolic acid, and citric acid at 100 μM concentration could be used for anti-wrinkling or protection from premature aging, which requires enhancement of collagen synthesis. Lactic acid, EGCG, resveratrol, and retinol that can inhibit collagen synthesis effectively in a dose-dependent manner may be used for anti-fibrosis treatment purposes.
From the journal
Molecules and Cells
ISSN : 1016-8478

Bibliographic information

Language:
English
Type:
Directory
In AGRIS since:
2009
Volume:
26
Issue:
6
Start Page:
625
End Page:
630
All titles:
"A Rapid and Sensitive Screening System for Human Type Ⅰ Collagen with the Aim of Discovering Potent Anti-Aging or Anti-Fibrotic Compounds"@eng
Other:
"Summary(En)"
"4ill., 40 ref."
Loading...

Bibliographic information

Language:
English
Type:
Directory
In AGRIS since:
2009
Volume:
26
Issue:
6
Start Page:
625
End Page:
630
All titles:
"A Rapid and Sensitive Screening System for Human Type Ⅰ Collagen with the Aim of Discovering Potent Anti-Aging or Anti-Fibrotic Compounds"@eng
Other:
"Summary(En)"
"4ill., 40 ref."