Anti-inflammatory Effect of MeOH Extract of Cibotium barometz in IFN-γ and LPS-stimulated Mouse Peritoneal Macrophage

Lee, J.Y., Woosuk University, Samrye; Ko, S.H., Woosuk University, Samrye; Lee, Y.J., Woosuk University, Samrye; Lee, S.Y., Woosuk University, Samrye; Park, H.J., Woosuk University, Samrye; Shin, T.Y., Center for Healthcare Technology Development; Jeon, H., Center for Healthcare Technology Development

Journal Article

Anti-inflammatory Effect of MeOH Extract of Cibotium barometz in IFN-γ and LPS-stimulated Mouse Peritoneal Macrophage [2010]

Lee, J.Y., Woosuk University, Samrye, Republic of Korea; Ko, S.H., Woosuk University, Samrye, Republic of Korea; Lee, Y.J., Woosuk University, Samrye, Republic of Korea; Lee, S.Y., Woosuk University, Samrye, Republic of Korea; et al.

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The rhizome of Cibotium barometz has been used for variety of bone disease as a traditional medicine. In the present study, we examined the antioxidant and anti-inflammatory activities of 85% methanol extract of C. barometz. C. barometz exhibited potent scavenging effect on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, superoxide radical and nitric oxide radical. In IFN-/γLPS-stimulated mouse peritoneal macrophage model, C. barometz suppressed nitric oxide production and IL-6 secretion dose-dependently. Moreover, C. barometz showed decreased iNOS and COX-2 expression without notable cytotoxicity. These results suggest that C. barometz may be an useful agent as an antioxidant and anti-inflammatory agent.