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Journal Article

Journal Article

Anti-tumor Effects of Codonopsis Lanceolata Extracts on Human Lung and Ovarian Cancer  [2011]

Cho, Y.R., Kangwon National University, Chuncheon, Republic of Korea; Kim, S.H., Kangwon National University, Chuncheon, Republic of Korea; Yoon, H.J., Kangwon National University, Chuncheon, Republic of Korea; Hong, S.Y., Kangwon National University, Chuncheon, Republic of Korea; et al.

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Codonopsis lanceolata L. (Campanulaceae) has long been used in traditional Korean medicine to treat bronchitis, cough, and inflammatory diseases, however, the efficacy of anti-tumor activities remains to be defined. In this study the effects of Codonopsis lanceolata (C. lanceolata) on proliferation, migration and adhesion in lung (A549, H1299) and ovarian cancer (SKOV-3) cells were investigated. To assess and compare the pharmacological effects and production places of C. lanceolata, the ethanolic extracts of C. lanceolata from different places in Korea (Hongseong, Yecheon, Yeongwol, Yanggu, Gangjin, and Hoengseong) were prepared. The extract from Hoengseong county did have only marginal anti-proliferative activity in all the cell lines tested, however, other extracts had little or no effect on cell proliferation. The extracts from Hongseong, Gangjin or Hoengseong county had partial anti-migratory activity in lung cancer cells, but not in ovarian cancer cells. In addition, the extract from Hoengseong county had partial anti-adhesive activity in ovarian cancer cells, however, other extracts did not affect cell adhesion in both lung and ovarian cancer cells. Taken together, these findings provide the first description of anti-tumor efficacy of C. lanceolata from different production places in Korea, and suggest that C. lanceolata from Hoengseong county may have therapeutic potential in lung and ovarian cancers.
From the journal
Food Engineering Progress
ISSN : 1226-4768

Bibliographic information

Language:
Korean
Type:
Directory
In AGRIS since:
2012
Volume:
15
Issue:
1
Start Page:
1
End Page:
5
All titles:
"Anti-tumor Effects of Codonopsis Lanceolata Extracts on Human Lung and Ovarian Cancer"@eng
Other:
"Summary(En)"
"3ill., 15 ref."
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Bibliographic information

Language:
Korean
Type:
Directory
In AGRIS since:
2012
Volume:
15
Issue:
1
Start Page:
1
End Page:
5
All titles:
"Anti-tumor Effects of Codonopsis Lanceolata Extracts on Human Lung and Ovarian Cancer"@eng
Other:
"Summary(En)"
"3ill., 15 ref."