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Journal Article

Journal Article

Lifespan Extension Property of Quercetin-3-O- ¥� -D-glucopyranoside-7-O- ¥� -L-rhamnopyranoside from Curcuma longa L. In Caenorhabditis elegans  [2014]

Ahn, D.R., Woosuk University, Jeonju, Republic of Korea; Lee, E.B., Woosuk University, Jeonju, Republic of Korea; Kim, B.J., Woosuk University, Jeonju, Republic of Korea; Lee, S.Y., Woosuk University, Jeonju, Republic of Korea; et al.

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After harvesting the medicinal parts of Curcuma longa, the remaining underground parts were discarded. From the remaining underground parts of Curcuma longa quercetin-3-O- ¥� -D-glucopyranoside-7-O- ¥� -L-rhamnopyranoside (Q37) was isolated. The antioxidant activities in vitro and lifespan-extension effect of Q37 were elucidated using the Caenorhabditis elegans. The 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging effect of Q37 showed similar potent activities in comparison with vitamin C. Q37 also showed potent superoxide quenching activities as measured by the riboflavin- and xanthine-originated superoxide quenching activity tests. Q37 prolonged lifespan of worms under normal culture condition. In terms of protective effect of Q37 on the stress conditions such as thermal and oxidative stresses, Q37-treated worms exhibited enhanced survival rate, as compared to control worms. To know the possible mechanism of Q37-mediated increased lifespan and stress resistance of worms, we examined the activities of Q37on superoxide dismutase (SOD), and invested intracellular reactive oxygen species (ROS) levels. The results revealed that Q37 was able to elevate SOD activity of worms and reduce intracellular ROS accumulation in a dose-dependent manner.
From the journal
Korean Journal of Pharmacognosy
ISSN : 0253-3073

Bibliographic information

Language:
Korean
Type:
Directory
In AGRIS since:
2015
Volume:
45
Issue:
4
Start Page:
275
End Page:
281
All titles:
"Lifespan Extension Property of Quercetin-3-O- ¥� -D-glucopyranoside-7-O- ¥� -L-rhamnopyranoside from Curcuma longa L. In Caenorhabditis elegans"@eng
Other:
"Summary(En)"
"7ill., 28 ref."
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Bibliographic information

Language:
Korean
Type:
Directory
In AGRIS since:
2015
Volume:
45
Issue:
4
Start Page:
275
End Page:
281
All titles:
"Lifespan Extension Property of Quercetin-3-O- ¥� -D-glucopyranoside-7-O- ¥� -L-rhamnopyranoside from Curcuma longa L. In Caenorhabditis elegans"@eng
Other:
"Summary(En)"
"7ill., 28 ref."