Cholinesterase Inhibitory Constituents from Capsosiphon fulvescens

Fang, Zhe, Catholic University of Daegu, Gyungsan; Jeong, S.Y., Catholic University of Daegu, Gyungsan; Choi, J.S., Pukyong National University, Busan; Min, B.S., Catholic University of Daegu, Gyungsan; Min, B.K., Catholic University of Daegu, Gyungsan; Woo, M.H., Catholic University of Daegu, Gyungsan

Journal Article

Cholinesterase Inhibitory Constituents from Capsosiphon fulvescens [2012]

Fang, Zhe, Catholic University of Daegu, Gyungsan, Republic of Korea; Jeong, S.Y., Catholic University of Daegu, Gyungsan, Republic of Korea; Choi, J.S., Pukyong National University, Busan, Republic of Korea; Min, B.S., Catholic University of Daegu, Gyungsan, Republic of Korea; et al.

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Nine compounds (1 - 9), α-linolenic acid (1), cis-5,8,11,14,17-elcosapentaenoic acid (2), phytol (3), loliolide (4), uridine (5), thymidine (6), deoxyadenosine (7), adenine (8), and adenosine (9), were isolated from the n-hexane, methylene chloride, ethyl acetate and n-butanol fractions of Capsosiphon fulvescens. The structures of these compounds were elucidated on the basis of spectroscopic evidence. Compounds 1 - 9 exhibited acetylcholinesterase (AChE) inhibitory activities with IC∧50 values ranging from 114.91 to 252.40 μM, whereas 2 - 4 showed butyrylcholinesterase (BChE) inhibitory activities with IC∧50 values ranging from 251.18 to 499.16 μM.