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Journal Article

Journal Article

Effect of Diosmin on Osteoblast Differentiation  [2017]

Kim, K.M., Daegu University, Gyeongsan, Republic of Korea; Jang, W.G., Daegu University, Gyeongsan, Republic of Korea;

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Diosmin is a compound that is widely distributed in citrus. The aim of this study was to examine the effects of diosmin on osteoblast differentiation using MC3T3-E1 preosteoblast cells. The effect of diosmin on mRNA expression levels of osteogenic genes in MC3T3E1 cells were determined by RT-PCR. Diosmin regulated expression of key osteogenic genes such as dNA-binding protein inhibitor (Id1), runt-related transcription factor 2 (Runx2), alkaline phosphatase (ALP), and osteocalcin (OC) during osteoblast differentiation, and promoted recovery of tumor necrosis factor (TNF)-α-reduced osteogenesis. Alizarin Red S staining was performed to evaluate mineralization. Diosmin enhanced mineralization and recovery of TNF-α-reduced osteoblast differentiation. These results suggest that diosmin may enhance osteoblast differentiation and recovery of TNF-α-reduced osteoblast differentiation, and it may be a candidate for treating osteoporosis.

From the journal

Journal of The Korean Society of Food Science and Nutrition
ISSN : 1226-3311

Bibliographic information

Language:
Korean
Type:
Directory
In AGRIS since:
2018
Volume:
46
Issue:
12
Start Page:
1462
End Page:
1467
All titles:
"Effect of Diosmin on Osteoblast Differentiation"@eng
Other:
"Summary(En)"
"1 table"
"4ill., 41 ref."
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Bibliographic information

Language:
Korean
Type:
Directory
In AGRIS since:
2018
Volume:
46
Issue:
12
Start Page:
1462
End Page:
1467
All titles:
"Effect of Diosmin on Osteoblast Differentiation"@eng
Other:
"Summary(En)"
"1 table"
"4ill., 41 ref."