The use of glucocorticoids induces a specific pathology in dogs called steroid hepatopathy. The objective of this study was to determine the possibility of the hepatoprotectants to decrease the corticosteroid-induced alteration in dogs’ liver functional condition. To reach the aim such blood serum enzymes as alaninaminotransferase (ALAT), gammaglutamyltranferase (GGT), alkaline phosphatase (AP) and corticosteroid-induced thermostable alkaline phosphatase (cAP) were analysed. The study took place in private veterinary clinics in Latvia, during 2013 – 2014, with the permission of dogs’ owners. Twenty animals, which received glucocorticoids due to present diagnosis, were divided into two groups. In the first group longlasting glucocorticoid methylprednisolone acetate injection was used once, while in the second group, the hepatoprotectants were used after the injection of glucocorticoids. It was discovered that after 45 days of hepatoprotectants use, blood enzymes were significantly lower (p is less than 0.05) than in dogs that did not receive hepatoprotectants. In the group where the hepatoprotectants were used the enzyme values reached the reference limits.