Written Paper

Anti-inflammatory evaluation of the leaf extracts of Senna occidentalis Linn  [2009]

Hani Idayu B. Fadzureena J. Mazura M P. Nuziah H. et al.

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Senna occidentalis (L.) Link from the family Fabaceae, a small shrub locally known as `kachang kota` is used in traditionaL medicine against fevers. tuberculosis,anaemia, liver complaints and as a reconstituent for general weakness and illness. In this study, various extracts from the leaves of S. occidentalis were evaluated for therapeutic potential as anti-inflammatory agents. The anti-inflammatory activity was tested using the hyaluronidase, lipoxygenase, xanthine oxidase assays and also an animal model of 12-0-tetradecanoylphorbol-13-acetate (TPA)-induced ear oedema. All thc extracts showed some degree of inhibitions against all the enzymes. The most significant activity was found to be in ethyl acetate and dichloromethane extracts, which gave 100% and 99% inhibition at 100 ug/ml against enzyme lipoxygenase (100%) and hyaluronidase, respectively. The hexane extract also demonstrated profound activity in both assays, while the ethyl acetate extract was the only one found to be effective in the xanthine oxidase assay with inhibition of 76%. In the TPA-induced ear oedema model, low to moderate activity was observed for all the extracts, with the dichloromethane extract being the most active with inhibition of 73% at a concentration of 2 mg/ear. This study provides a scientific basis for the use of this plant for the treatment of inflammation-related illnesses.

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Proceedings of the Seminar on Medicinal and Aromatic Plants (MAPS 2008)