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Universiti Pertanian Malaysia was established in 1971 as a result of the merger between the College of Agriculture, Malaya and the Faculty of Agriculture, University of Malaya. The Library of the College of Agriculture, Malaya thus became the Universiti Pertanian Malaysia Library. When the university was named as Universiti Putra Malaysia (UPM) in 1997, the Library became the Universiti Putra Malaysia Library. As of 23rd May 2002, the Library has been named as Perpustakaan Sultan Abdul Samad (PSAS), Universiti Putra Malaysia, after the late gre [...]

Journal Article

Journal Article

Anti-inflammatory evaluation of the leaf extracts of Senna occidentalis Linn  [2009]

Hani Idayu B.; Fadzureena J.; Mazura M P.; Nuziah H.; et al.

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Senna occidentalis (L.) Link from the family Fabaceae, a small shrub locally known as `kachang kota` is used in traditionaL medicine against fevers. tuberculosis,anaemia, liver complaints and as a reconstituent for general weakness and illness. In this study, various extracts from the leaves of S. occidentalis were evaluated for therapeutic potential as anti-inflammatory agents. The anti-inflammatory activity was tested using the hyaluronidase, lipoxygenase, xanthine oxidase assays and also an animal model of 12-0-tetradecanoylphorbol-13-acetate (TPA)-induced ear oedema. All thc extracts showed some degree of inhibitions against all the enzymes. The most significant activity was found to be in ethyl acetate and dichloromethane extracts, which gave 100% and 99% inhibition at 100 ug/ml against enzyme lipoxygenase (100%) and hyaluronidase, respectively. The hexane extract also demonstrated profound activity in both assays, while the ethyl acetate extract was the only one found to be effective in the xanthine oxidase assay with inhibition of 76%. In the TPA-induced ear oedema model, low to moderate activity was observed for all the extracts, with the dichloromethane extract being the most active with inhibition of 73% at a concentration of 2 mg/ear. This study provides a scientific basis for the use of this plant for the treatment of inflammation-related illnesses.

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Bibliographic information

Language:
English
Type:
Other
In AGRIS since:
2015
Start Page:
296
End Page:
302
Publisher:
Forest Research Institute Malaysia
ISBN:
978-967-5221-26-2
All titles:
" Anti-inflammatory evaluation of the leaf extracts of Senna occidentalis Linn "

From the journal

Proceedings of the Seminar on Medicinal and Aromatic Plants (MAPS 2008)