Journal Article

Journal article

Hypoglycemic and anti-inflammatory effects of tea extracts and ent - kaurenoic acid from yacon (Smallanthus sonchifolius)  [2012]

Alimboyoguen, A.B., Cavite State Univ., Indang, 4122 Cavite (Philippines); Ragasa, C., De La Salle Univ., Manila (Philippines); Raga, D., Philippines Univ. Diliman, Diliman, Quezon City (Philippines);

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Smallanthus sonchifelius (Asteraceae), commonly known as yacon, is currently introduced and marketed in the Philippines as a type of tea possessing anti-diabetic property. Yacon is rich in tractor oligosaccharide, which has been associated with better control of cardiovascular diseases, diabetes and prevention of cancer. In this study, the biological activities such as hypoglycemic and inflammatory effects of aqueous leaf tea extract and ent-kaurenoic acid, a diterpene, which has been isolated from CH2Cl2 extract from the leaves and tubers of yacon were investigated. Results showed that hypoglycemic activity was observed in normoglycemic mice orally administered with the aqueous Smallantus sonchifolius leaf tea extract, alloxan-indujced diabetic mice orally administered with ent-kaurenoic acid and normoglycemic mice intraperitoneally administered with the compound from S. sonchifolius leaves. A single dose administration of 50 mg/kg BW yacon leaf tea extract demonstrated immediate but relatively short hypoglycemic activity, with significant effects observed during 1-2h. Similarly, administration with 100 mg/kg BW yacon leaf tea extract obtained by heavy stirring in hot water demonstrated a more potent activity compared to the positive control at 1.5-2.0h. Oral administration of the compound did not affect the blood glucose level of the alloxan induced diabetic mice, but a single intraperitoneal injection of 10 mg/kg BW in normoglycemic mice had consistent
percent blood glucose reduction persisting from 1 to 2 h observation periods. Furthermore, the anti-inflammatory potential of yacon was observed in mice orally treated with ent-kaurenoic acid (100 mg/kg mouse). Emigration of pleurisy in comparison with the control (2.15 x 10.5). Treatment of mice effectively reduced pulmonary inflammation by 98.1 ± 2.0%, in a similar manner to that of Diclofenac, a well known anti-inflammatory drug (85.2 +- 15.9%).

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Philippine Journal of Crop Science (Philippines)

ISSN : 0115-463X