Written Paper

Anti-inflammatory steroid (Prednisolone) and its effect on the adrenal gland  [2000]

Essawy, A.E. (Alexandria Univ. (Egypt). Dept. of Zoology) Sakr, S.A. Saleh, A.T. El-Salmy, F.

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Administration of an anti-inflammatory steroidal drug-Prednisolone- (0.85 mg/kg body weight, daily for 10 days) to adult toads Bufo tibamicus resulted in suppression of the function of the adrenal gland, as shown by a significant increase in the lipid droplets, autolysis of mitochondria and disorganization and degranulation of rER in the steroidogenic cells. Furthermore, chromaffin cells (catecholamines secreting cells), showed a marked decrease in the number of chromaffin granules and degenerative changes in the nuclei. These serious side effects should be taken into consideration when using this drug.

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Pakistan Journal of Biological Sciences (Pakistan)

ISSN : 1028-8880