Written Paper

Histopathological and ultrastructural studies on the toxic effect of prianilC-R (Lithium carbonate) in mouse kidney  [2004]

Abdel-Meguid, N. Essawy, A. Ali, A. Sedky, A.,Alexandria Univ. (Egypt).Dept. of Zoology

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This study was carried out to investigate the histopathological andultrastructural alterations in the kidney of Swiss albino mice in response tothe administration of prianil C-R (lithium carbonate ) at a dose level of 2.32mg/mouse daily for 30 days (therapeutic dose) and 0.58 mg/mouse daily for 90days ( quarter the therapeutic dose). Our results demonstrated severechanges involved both glomeruli and renal tubules in mice treated with highdose of lithium. The histopathological changes of the glomeruli includedhypertrophied glomeruli, schrinked urinary space and increased mesangialmatrix. Altered podocytes, ballooning, hypertrophy or focal fusion of thesecondary foot proces and thickening of the glomerular basement membranewere recorded. The proximal convoluted tubular cells were severly affected.They have pleomorphic irregular shaped nuclei, swollen mitochondria withvesicular cristae, dilated rough endoplasmic reticulum and hypertrophied Golgiapparatus. The brush border was lost in some areas of proximal tubular cells.The changes in the distal convoluted tubular cells are less pronounced andincluded dilated nuclear membrane, hypertrophied Golgi apparatus, abnormalmitochondria and vacuolated cytoplasm. The pathological alteration induced inthe renal tissue after low dose of prianil C-R were approaching those inducedby the high dose, however, they were less remarkable.