Antibacterial activity of different solvent extracts of leaves and water extract of stem (branch) and leaves of Murraya koenigii were found effective against bacterial species strains such as Bacillus licheniformis, Bacillus aureus, Eschericia coli. Salmonella typhimuriurn, Staphylococcus aureus, Bacillus subtilis. The results confirmed the antimicrobial effect of Murrayakoenigii extract against human pathogenic bacteria. Antifungal activity was also investigated against Fusarium moniliforme, Fusarium oxysporum, Macrophomina phaseolina and Rhizoctonia solanii. The extract inhibited the radial growth of test fungi. Anthelminthic activity of Murraya koenigii was also detected in the different solvent extracts of leaves. Phytochemical screening of Murraya leaf extract was also performed which confirmed the presence of various proteins, saponins, phenolics, alkaloids and terpenes, Additionally, anthocyanins, flavonoids and soluble phenols were estimated to be in ample amounts. The antibacterial activity is possibly due to antioxidant protein of curry leaf. Antifungal and anthelmintic activities are presumably due to phenolics, alkaloids or terpenes.