Journal article
The inhibition of some cancers and the promotion of others by folic acid, vitamin B12, and their antagonists. [1983]
Herbert V.; National Diabetes Information Clearinghouse (USA). National Institute of Arthritis, Diabetes and Digestive and Kidney Diseases (USA). [Corporate Author]
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A technical review suggests the hypothesis that folate or vitamin B12 deficiency (or any other cause of failure to methylate DNA and/or RNA) can activate malignancy by hypomethylation of oncogenes, and that the methylating oncogenes can inhibit malignancy by making them dormant. Specific attention is given to: the effects of folate deficiency; the role of vitamin B12; and studies on suppression testing to measure folate and vitamin B12 deficiencies in terms of slowing DNA synthesis.(wz).
