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The National Agricultural Library is one of four national libraries of the United States, with locations in Beltsville, Maryland and Washington, D.C. It houses one of the world's largest and most accessible agricultural information collections and serves as the nexus for a national network of state land-grant and U.S. Department of Agriculture field libraries. In fiscal year 2011 (Oct 2010 through Sept 2011) NAL delivered more than 100 million direct customer service transactions.

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Journal Article

Journal Article

Availability of polyphenols in fruit beverages subjected to in vitro gastrointestinal digestion and their effects on proliferation, cell-cycle and apoptosis in human colon cancer Caco-2 cells  [2009]

Cilla, Antonio; González-Sarrías, Antonio; Tomás-Barberán, Francisco A.; Espín, Juan Carlos; et al.

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Three fruit beverages: Fb (grape-orange-apricot), FbFe (Fb+iron sulphate) and FbFeM (FbFe+skimmed milk) were subjected to in vitro gastrointestinal digestion. Addition of Fe and milk decreased the phenolic content of Fb by 13% and 55%, respectively. The digestion process decreased the phenolic content by 47%, 60%, and 70% in Fb, FbFe and FbFeM with respect to the initial, non-digested, Fb. Caco-2 cells were incubated for 4h daily for four days or continuously for 24h with bioaccessible fractions obtained after the digestion (digests). Polyphenols were not metabolised by Caco-2 cells. Fb digest (~50μM total phenolics) was the sample that led to the highest inhibition of cell proliferation under the two experimental conditions. Fb digest did not induce apoptosis but ceased cell-cycle in the S-phase which is associated to a decrease in B1 and D1 cyclin levels upon incubation for 24h.
From the journal
Food chemistry
ISSN : 0308-8146

Bibliographic information

Language:
English
Type:
Journal Article
In AGRIS since:
2013
Volume:
114
Issue:
3
Start Page:
813
End Page:
820
Publisher:
[Amsterdam]: Elsevier Science
All titles:
"Availability of polyphenols in fruit beverages subjected to in vitro gastrointestinal digestion and their effects on proliferation, cell-cycle and apoptosis in human colon cancer Caco-2 cells"@eng
Other:
"Includes references"
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Bibliographic information

Language:
English
Type:
Journal Article
In AGRIS since:
2013
Volume:
114
Issue:
3
Start Page:
813
End Page:
820
Publisher:
[Amsterdam]: Elsevier Science
All titles:
"Availability of polyphenols in fruit beverages subjected to in vitro gastrointestinal digestion and their effects on proliferation, cell-cycle and apoptosis in human colon cancer Caco-2 cells"@eng
Other:
"Includes references"