AGRIS

Data provider:

Icon data provider

The National Agricultural Library is one of four national libraries of the United States, with locations in Beltsville, Maryland and Washington, D.C. It houses one of the world's largest and most accessible agricultural information collections and serves as the nexus for a national network of state land-grant and U.S. Department of Agriculture field libraries. In fiscal year 2011 (Oct 2010 through Sept 2011) NAL delivered more than 100 million direct customer service transactions.

Active (Data provider submitted metadata in the last calendar year)
Journal Article

Journal Article

Honokiol inhibits H₂O₂-induced apoptosis in human lens epithelial cells via inhibition of the mitogen-activated protein kinase and Akt pathways  [2011]

Tang, Xiajing; Yao, Ke; Zhang, Li; Yang, Yunmei; et al.

Access the full text

Oxidative stress-induced apoptosis in lens epithelial cells plays an important role in cataract formation, and its prevention may be of therapeutic interest. This study was performed to investigate the protective effect and mechanisms of honokiol on H₂O₂-induced apoptosis in human lens epithelial (HLE) cells. HLE cells (SRA01-04) were pretreated with honokiol at concentrations of 5μM, 10μM and 20μM before 50μM H₂O₂ treatment. The results demonstrated that pretreatment of honokiol inhibited the activation of caspase-3 and caspase-9 and downregulated the expression of Bcl-2. Mechanistically, honokiol suppressed H₂O₂-induced phosphorylation of ERK1/2, p38 mitogen-activated protein kinase (MAPK), JNK and Akt. Honokiol also inhibited H₂O₂-induced nuclear factor-κB (NF-κB)/p65 phosphorylation and translocation in HLE cells. These results demonstrate that honokiol suppresses H₂O₂-induced HLE cell apoptosis via interference with the MAPKs, Akt and NF-κB signaling, suggesting that honokiol might have a potential effect against cataract formation.
From the journal
European journal of pharmacology
ISSN : 0014-2999

Bibliographic information

Language:
English
Type:
Journal Article
In AGRIS since:
2015
Volume:
650
Issue:
1
Start Page:
72
End Page:
78
Publisher:
Elsevier B.V.
All titles:
"Honokiol inhibits H₂O₂-induced apoptosis in human lens epithelial cells via inhibition of the mitogen-activated protein kinase and Akt pathways"@eng
Loading...

Bibliographic information

Language:
English
Type:
Journal Article
In AGRIS since:
2015
Volume:
650
Issue:
1
Start Page:
72
End Page:
78
Publisher:
Elsevier B.V.
All titles:
"Honokiol inhibits H₂O₂-induced apoptosis in human lens epithelial cells via inhibition of the mitogen-activated protein kinase and Akt pathways"@eng