AGRIS

Data provider:

Icon data provider

The National Agricultural Library is one of four national libraries of the United States, with locations in Beltsville, Maryland and Washington, D.C. It houses one of the world's largest and most accessible agricultural information collections and serves as the nexus for a national network of state land-grant and U.S. Department of Agriculture field libraries. In fiscal year 2011 (Oct 2010 through Sept 2011) NAL delivered more than 100 million direct customer service transactions.

Active (Data provider submitted metadata in the last calendar year)
Journal Article

Journal Article

Isolation and identification of casein-derived dipeptidyl-peptidase 4 (DPP-4)-inhibitory peptide LPQNIPPL from gouda-type cheese and its effect on plasma glucose in rats  [2012]

Uenishi, Hiroshi; Kabuki, Toshihide; Seto, Yasuyuki; Serizawa, Atsushi; et al.

Access the full text

A water-soluble extract of a gouda-type cheese showed dipeptidyl-peptidase 4 (DPP-4)-inhibitory activity, which should improve glucose tolerance in type 2 diabetes. With liquid chromatography, we obtained four active fractions from the water-soluble extract and analysed the constituent peptides with liquid chromatography/mass spectrometry. Four peptides with the X–Pro-structure showed IC₅₀ values of <200 μm. β-Casein peptide residues 70–77 (β-CN f70–77; LPQNIPPL) showed the highest DPP-4-inhibitory activity, which increased during the ripening period. Glucose tolerance tests were performed in rats orally administered synthesized LPQNIPPL (30 mg 100 g⁻¹ rat weight) with a cross-over experimental design. The post-prandial area under the blood glucose curve was significantly reduced (P < 0.02) in the LPQNIPPL-administered group compared with that in the placebo-treated group. This is the first report that has identified DPP-4-inhibitory casein-derived peptides from gouda-type cheese with an effect on plasma glucose in a rat model.
From the journal
International dairy journal
ISSN : 0958-6946

Bibliographic information

Language:
English
Type:
Journal Article
In AGRIS since:
2015
Volume:
22
Issue:
1
Start Page:
24
End Page:
30
Publisher:
Elsevier Ltd
All titles:
"Isolation and identification of casein-derived dipeptidyl-peptidase 4 (DPP-4)-inhibitory peptide LPQNIPPL from gouda-type cheese and its effect on plasma glucose in rats"@eng
Loading...

Bibliographic information

Language:
English
Type:
Journal Article
In AGRIS since:
2015
Volume:
22
Issue:
1
Start Page:
24
End Page:
30
Publisher:
Elsevier Ltd
All titles:
"Isolation and identification of casein-derived dipeptidyl-peptidase 4 (DPP-4)-inhibitory peptide LPQNIPPL from gouda-type cheese and its effect on plasma glucose in rats"@eng