The ecological model of modern medicine has acquired a new quality and has become one of the leading models. In this regard, the establishment of ecological and biogeochemical determinants of health is a real problem. Along with the socio-economic and environmental-demographic challenges of the North development, the health issue takes a crucial place. The Yakutia population has been exposed to a number of adverse natural factors, as well as anthropogenic factors. Because of this, the environmentally induced morbidity is significantly increased, which leads to pathology of the major functional systems.