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The National Agricultural Library is one of four national libraries of the United States, with locations in Beltsville, Maryland and Washington, D.C. It houses one of the world's largest and most accessible agricultural information collections and serves as the nexus for a national network of state land-grant and U.S. Department of Agriculture field libraries. In fiscal year 2011 (Oct 2010 through Sept 2011) NAL delivered more than 100 million direct customer service transactions.

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Journal Article

Journal Article

Antiviral Activity of Polymethoxylated Flavones from “Guangchenpi”, the Edible and Medicinal Pericarps of Citrus reticulata ‘Chachi’  [2014]

Hu, Jiao-Jiao; Wu, Xia; Li, Man-Mei; Li, Guo-Qiang; et al.

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The present study found that the supercritical fluid extract of “Guangchenpi” possessed in vitro antiviral activity against respiratory syncytial virus (RSV). Bioassay-guided isolation and identification of this extract led to obtain five active polymethoxylated flavones (1–5). Cytopathic effect (CPE) reduction assay exhibited that tangeretin (2) and nobiletin (3), two major polymethoxylated flavones in the extract, possessed better anti-RSV effect comparable to the positive control ribavirin. Plaque reduction assay revealed that tangeretin dose-dependently inhibited RSV-induced plaque formation on the HEp-2 cells. This polymethoxylated flavone mainly affected the intracellular replication of RSV, and it also could inhibit RSV entry into the HEp-2 cells. Further investigations with quantitative real-time PCR and confocal and Western blot assays indicated that tangeretin downregulated the expression of RSV phosphoprotein (P protein). Results suggest the potential application of the supercritical fluid extract of “Guangchenpi” and tangeretin in the treatment and the prevention of RSV infection.
From the journal
Journal of agricultural and food chemistry
ISSN : 0021-8561

Bibliographic information

Language:
English
Type:
Journal Article
In AGRIS since:
2016
Volume:
62
Issue:
10
Start Page:
2182
End Page:
2189
Publisher:
American Chemical Society, Books and Journals Division
All titles:
"Antiviral Activity of Polymethoxylated Flavones from “Guangchenpi”, the Edible and Medicinal Pericarps of Citrus reticulata ‘Chachi’"@eng
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Bibliographic information

Language:
English
Type:
Journal Article
In AGRIS since:
2016
Volume:
62
Issue:
10
Start Page:
2182
End Page:
2189
Publisher:
American Chemical Society, Books and Journals Division
All titles:
"Antiviral Activity of Polymethoxylated Flavones from “Guangchenpi”, the Edible and Medicinal Pericarps of Citrus reticulata ‘Chachi’"@eng