Five flavones were isolated from Chrysanthemum coronarium L., four of which were isolated for the first time from the genus Chrysanthemum. Two were the flavonoid aglycones 5,7- dihydroxy-3,6,4’-trimethoxyflavone (1) and scutellarin-6,7-dimethyl ether (2). A new flavonoid glycoside, apigenin-7-O-[2’’(6’’’-O-b-ß-acetylglucopyranosyl)]-6’’-O-acetylglucopyranoside (3), along with two known ones, i. e. apigenin-7-O-(2’’-O-b-ß-glucopyranosyl)-b-ß-glucopyranoside (4) and 6-methoxy quercetin-7-O-b-ß-glucopyranoside (5), were identified. Structures were elucidated by NMR and MS. The therapeutic value of petroleum ether, ethyl acetate, and methanol extracts, respectively, in rats suffering from hypercholesterolemia - as a consequence of high-fat diet - and hyperglycemia - as a consequence of hypercholesterolemia and low doses of streptozotocin - was investigated through determination of biochemical markers and histopathology. The ethyl acetate and methanol extracts showed remarkable results, followed by the petroleum ether extract