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The National Agricultural Library is one of four national libraries of the United States, with locations in Beltsville, Maryland and Washington, D.C. It houses one of the world's largest and most accessible agricultural information collections and serves as the nexus for a national network of state land-grant and U.S. Department of Agriculture field libraries. In fiscal year 2011 (Oct 2010 through Sept 2011) NAL delivered more than 100 million direct customer service transactions.

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Journal Article

Journal Article

Isolation of two Ochrobactrum sp. strains capable of degrading the nootropic drug—Piracetam  [2017]

Marta; Woźniak-Karczewska; Monika; Čvančarová; et al.

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Piracetam (2-oxo-1-pyrrolidine acetamide) is a popular cognitive enhancer, which has recently been detected in waste and drinking water. Nootropic drugs are designed to affect human metabolism and act on the nervous system, but their environmental effects have yet to be the subject of detailed studies. In this report, we present the efficient biodegradation of the cognitive enhancer, piracetam. Two bacterial strains capable of using this compound as the sole carbon source were isolated and later identified as Ochrobactrum anthropi strain MW6 and Ochrobactrum intermedium strain MW7. The compound's mineralization and the cleavage of the heterocyclic ring were shown in the experiments with 14C-labeled piracetam. This is also the first report of a pharmaceutical's degradation by the Ochrobactrum genus. This study presents model microorganisms that can be used in further investigation of piracetam's degradation pathways as well as enzymes and genes involved in the process.
From the journal
New biotechnology
ISSN : 1871-6784

Bibliographic information

Language:
English
Type:
Journal Article
In AGRIS since:
2017
Publisher:
Elsevier B.V.
All titles:
"Isolation of two Ochrobactrum sp. strains capable of degrading the nootropic drug—Piracetam"@eng
Other:
"Pre-press version"
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Bibliographic information

Language:
English
Type:
Journal Article
In AGRIS since:
2017
Publisher:
Elsevier B.V.
All titles:
"Isolation of two Ochrobactrum sp. strains capable of degrading the nootropic drug—Piracetam"@eng
Other:
"Pre-press version"