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The National Agricultural Library is one of four national libraries of the United States, with locations in Beltsville, Maryland and Washington, D.C. It houses one of the world's largest and most accessible agricultural information collections and serves as the nexus for a national network of state land-grant and U.S. Department of Agriculture field libraries. In fiscal year 2011 (Oct 2010 through Sept 2011) NAL delivered more than 100 million direct customer service transactions.

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Journal Article

Journal Article

low‐protein diet induces body weight loss and browning of subcutaneous white adipose tissue through enhanced expression of hepatic fibroblast growth factor 21 (FGF21)  [2017]

Pérez‐Martí, Albert; Garcia‐Guasch, Maite; Tresserra‐Rimbau, Anna; Carrilho‐Do‐Rosário, Alexandra; et al.

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SCOPE: Fibroblast growth factor 21 (FGF21) is considered a promising therapeutic candidate for the treatment of obesity. Since FGF21 production is regulated by various nutritional factors, we analyze the impact of low protein intake on circulating levels of this growth hormone in mice and in a sub cohort of the PREDIMED (Prevención con Dieta Mediterránea) trial. We also describe the role of hepatic FGF21 in metabolic adaptation to a low‐protein diet (LPD). METHODS AND RESULTS: We fed control and liver‐specific Fgf21 knockout (LFgf21KO) mice a LPD. This diet increased FGF21 production by inducing its overexpression in liver, and this correlated with a body weight decrease without changes in food intake. The LPD also caused FGF21‐dependent browning in subcutaneous white adipose tissue (scWAT), as indicated by an increase in the expression of uncoupling protein 1 (UCP1). In a subgroup of 78 individuals from the PREDIMED trial, we observed an inverse correlation between protein intake and circulating FGF21 levels. CONCLUSION: Our results reinforce the involvement of FGF21 in coordinating energy homeostasis under a range of nutritional conditions. Moreover, here we describe an approach to increase the endogenous production of FGF21, which if demonstrated functional in humans, could generate a treatment for obesity.
From the journal
Molecular nutrition & food research
ISSN : 1613-4125

Bibliographic information

Language:
English
Type:
Journal Article
In AGRIS since:
2018
Volume:
61
Issue:
8
Publisher:
John Wiley & Sons, Ltd
All titles:
"low‐protein diet induces body weight loss and browning of subcutaneous white adipose tissue through enhanced expression of hepatic fibroblast growth factor 21 (FGF21)"@eng
Other:
"JOURNAL ARTICLE"
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Bibliographic information

Language:
English
Type:
Journal Article
In AGRIS since:
2018
Volume:
61
Issue:
8
Publisher:
John Wiley & Sons, Ltd
All titles:
"low‐protein diet induces body weight loss and browning of subcutaneous white adipose tissue through enhanced expression of hepatic fibroblast growth factor 21 (FGF21)"@eng
Other:
"JOURNAL ARTICLE"