AGRIS

Data provider:

Icon data provider

The National Agricultural Library is one of four national libraries of the United States, with locations in Beltsville, Maryland and Washington, D.C. It houses one of the world's largest and most accessible agricultural information collections and serves as the nexus for a national network of state land-grant and U.S. Department of Agriculture field libraries. In fiscal year 2011 (Oct 2010 through Sept 2011) NAL delivered more than 100 million direct customer service transactions.

Active (Data provider submitted metadata in the last calendar year)
Journal Article

Journal Article

Further New Gypenosides from Jiaogulan (Gynostemma pentaphyllum)  [2017]

Wang, Jun; Yang, Jun-Li; Zhou, Pan-Pan; Meng, Xian-Hua; et al.

Access the full text

Jiaogulan (Gynostemma pentaphyllum) has been widely used as a herbal tea, dietary supplement, and vegetable in Asian countries. In this study, six new gypenosides (1–6) were isolated from the aerial parts of G. pentaphyllum. Their molecular structures were elucidated through spectroscopic analysis and acid hydrolysis. Gypenosides 1 and 2 represented the first example of a dammar-21-O- glucopyranoside without any unsaturated functional group and a dammar-3-O-glucopyranosyl-25-O-glucopyranoside without any cyclization in the side chain, respectively. In addition, gypenosides 5 and 6 exhibited the first example of a 24-hydroperoxy-19-oxo-dammarane triterpenoid and 19-oxo-dammar-21-O-glucopyranoside with a saturated side chain, respectively. Gypenoside 5 was found to possess protein tyrosine phosphatase 1B inhibitory activity, with an IC50 value of 8.2 ± 0.9 μM, and moderate cytotoxicity against human breast cancer cells MCF7, MCF7/ADR, and MDA-MB-231, with IC50 values ranging from 10.5 ± 1.4 to 14.2 ± 2.6 μM. The outcome of the study provided crucial information regarding the structural diversity and health benefits of gypenosides.
From the journal
Journal of agricultural and food chemistry
ISSN : 0021-8561

Bibliographic information

Language:
English
Type:
Journal Article
In AGRIS since:
2018
Volume:
65
Issue:
29
Extent:
5926-5934
Publisher:
American Chemical Society, Books and Journals Division
All titles:
"Further New Gypenosides from Jiaogulan (Gynostemma pentaphyllum)"@eng
Loading...

Bibliographic information

Language:
English
Type:
Journal Article
In AGRIS since:
2018
Volume:
65
Issue:
29
Extent:
5926-5934
Publisher:
American Chemical Society, Books and Journals Division
All titles:
"Further New Gypenosides from Jiaogulan (Gynostemma pentaphyllum)"@eng