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The National Agricultural Library is one of four national libraries of the United States, with locations in Beltsville, Maryland and Washington, D.C. It houses one of the world's largest and most accessible agricultural information collections and serves as the nexus for a national network of state land-grant and U.S. Department of Agriculture field libraries. In fiscal year 2011 (Oct 2010 through Sept 2011) NAL delivered more than 100 million direct customer service transactions.

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Journal Article

Journal Article

Antioxidant properties of the flavonoid fisetin: An updated review of in vivo and in vitro studies  [2017]

Naeimi, Alireza Farsad; Alizadeh, Mohammad;

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The overproduction of reactive oxygen species (ROS) by oxidative damage of the cellular ingredients has a substantial role in the development of many diseases, such as cancer. Fisetin (3, 3′, 4′, 7 –tetrahydroxyflavone) is a less familiar but widely distributed plant-based flavonoid in foods. Recently, several biological activities of fisetin have been identified including neuroprotective, anti-inflammatory and anticarcinogenic effects. The antioxidant activity of fisetin as a flavonoid has been shown in several studies, but limited comprehensive data is available on the mechanistic aspects of its antioxidant activity.This paper reviewed the reports regarding intracellular antioxidant effects of fisetin in different settings, with a comparative view to the other structurally related flavonoids. Additionally, we have summarized the suggested mechanisms of action for fisetin considering its possible interactions with signaling pathways. Some directions for future studies, reinforcing the antioxidant capacity of the human body against oxidative stress and related disorders are identified.Fisetin, when transmitted through cellular membranes, can interact with diverse redox-related signaling pathways. These pathways are mainly NF-κB, Nrf2, MAPK, and PI3K/Akt, so fisetin exerts its effective antioxidant activity through multiple mechanisms such as reinforcing enzymatic and non-enzymatic intracellular antioxidants, chelating transition metal ions and actin
g as a substrate for oxidoreductase activity. Therefore, the antioxidant effects of fisetin include more than just free radical scavenging. In the future, other cellular pathways that are also possibly involved should be explored and conducting well-designed clinical trials using low-doses of fisetin should be considered.
From the journal
Trends in food science & technology
ISSN : 0924-2244

Bibliographic information

Language:
English
Type:
Journal Article
In AGRIS since:
2018
Publisher:
Elsevier Ltd
All titles:
"Antioxidant properties of the flavonoid fisetin: An updated review of in vivo and in vitro studies"@eng
Other:
"Pre-press version"
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Bibliographic information

Language:
English
Type:
Journal Article
In AGRIS since:
2018
Publisher:
Elsevier Ltd
All titles:
"Antioxidant properties of the flavonoid fisetin: An updated review of in vivo and in vitro studies"@eng
Other:
"Pre-press version"