Journal Article
Microwave-Assisted Organocatalytic Intramolecular Knoevenagel/Hetero DielsâAlder Reaction with O-(Arylpropynyloxy)-Salicylaldehydes: Synthesis of Polycyclic Embelin Derivatives [2016]
MartiÌn-Acosta, Pedro; Feresin, Gabriela; Tapia, Alejandro; EsteÌvez-Braun, Ana;
A highly efficient and regioselective approach to new polycyclic embelin derivatives through a domino Knoevenagel condensation/intramolecular hetero DielsâAlder reaction using O-(arylpropynyloxy)-salicylaldehydes in the presence of ethylenediamine diacetate (EDDA) is reported. This organocatalyzed protocol is compatible toward a wide range of aryl-substituted alkynyl ethers with electron-donating and electron-withdrawing groups. When other active methylene compounds were subjected to this domino reaction the corresponding adducts were obtained in high yield.
