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The National Agricultural Library is one of four national libraries of the United States, with locations in Beltsville, Maryland and Washington, D.C. It houses one of the world's largest and most accessible agricultural information collections and serves as the nexus for a national network of state land-grant and U.S. Department of Agriculture field libraries. In fiscal year 2011 (Oct 2010 through Sept 2011) NAL delivered more than 100 million direct customer service transactions.

Journal Article

Journal Article

Screening and identification of potent α-glycosidase inhibitors from Gardenia jasminoides Ellis  [2018]

Hua, D.; Luo, W.; Duan, J.; Jin, D.; et al. SAAB [Corporate Author]

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The α-glycosidase inhibition assay is used to examine the inhibition activity of traditional Chinese medicines through extraction with methanol. The α-glycosidase inhibition activity of the isolated compounds is measured by α-glycosidase inhibition assay and compared with Acarbose. Molecular docking is implemented to study the interaction between isolated compounds and CtMGAM (maltase–glucoamylase-C) or NtMGAM (maltase–glucoamylase-N). Compared with those of Acarbose, the methanol extract of Gardenia jasminoides Ellis has a higher activity to inhibit α-glycosidase among the 74 traditional Chinese medicines. Geniposide and Gardenoside, isolated compounds from Gardenia jasminoides Ellis, have better inhibition activity (IC50 values of 0.35 and 0.46 mg/ml, respectively) than Acarbose (IC50 values of 0.75 mg/ml). The molecular docking results show that Geniposide and Gardenoside have specific binding affinities with CtMGAM and can be considered comparable to those of Acarbose. Our findings illuminate the possible anti-diabetic mechanism of Gardenia jasminoides Ellis and support its use for the treatment of diabetes.
From the journal
South African journal of botany
ISSN : 0254-6299

Bibliographic information

Language:
English
Type:
Journal Article
In AGRIS since:
2019
Volume:
119
Issue:
5
Extent:
377-382
Publisher:
Elsevier B.V.
All titles:
"Screening and identification of potent α-glycosidase inhibitors from Gardenia jasminoides Ellis"@eng
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Bibliographic information

Language:
English
Type:
Journal Article
In AGRIS since:
2019
Volume:
119
Issue:
5
Extent:
377-382
Publisher:
Elsevier B.V.
All titles:
"Screening and identification of potent α-glycosidase inhibitors from Gardenia jasminoides Ellis"@eng