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The National Agricultural Library is one of four national libraries of the United States, with locations in Beltsville, Maryland and Washington, D.C. It houses one of the world's largest and most accessible agricultural information collections and serves as the nexus for a national network of state land-grant and U.S. Department of Agriculture field libraries. In fiscal year 2011 (Oct 2010 through Sept 2011) NAL delivered more than 100 million direct customer service transactions.

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Journal Article

Journal Article

Intermittent fasting beneficial effects on the steatosis and inflammation of the liver in mice fed a high-fat or a high-fructose diet  [2019]

Marinho, Thatiany de Souza; Ornellas, Fernanda; Barbosa-Da-Silva, Sandra; Mandarim-De-Lacerda, Carlos A.; et al.

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Intermittent fasting (‘IF’) is a nutritional intervention whose significant metabolic effects on the liver are not yet fully understood.We used cellular and molecular techniques to investigate the effects of ‘IF’ on body mass (BM), lipid profile, glucose metabolism, and the liver lipogenesis, beta-oxidation, and inflammation. Male C57BL/6 mice three-month-old were fed Control (C, 10% KCal fat), High-fat (HF, 50% KCal fat) or High-fructose (HFr, 50% KCal fructose) diets for eight weeks, then half of the animals were submitted to ‘IF’ (one day fed, one day fast) for an additional four weeks.Although food intake in the fed day has not been different between the groups, HF and HFr showed diminished BM, total cholesterol and triacylglycerol. Also, plasmatic adiponectin increased in HFr and leptin decreased in HF. Oral glucose tolerance test and insulin were ameliorated by ‘IF,’ regardless of the diet consumed (HF or HFr), as well as decreased hepatic lipogenesis and increased beta-oxidation markers, resulting in a reduction of the hepatic steatosis and inflammation.There were beneficial effects of 'IF' even with the continuity of the obesogenic diet and proinflammatory diet in mice. The beneficial effects of 'IF' on glucose metabolism and the liver metabolism and inflammation recommend 'IF' as coadjutant factor treating hepatic metabolic troubles and steatosis.
From the journal
Nutrition
ISSN : 0899-9007

Bibliographic information

Language:
English
Type:
Journal Article
In AGRIS since:
2019
Publisher:
Elsevier Inc.
All titles:
"Intermittent fasting beneficial effects on the steatosis and inflammation of the liver in mice fed a high-fat or a high-fructose diet"@eng
Other:
"Pre-press version"
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Bibliographic information

Language:
English
Type:
Journal Article
In AGRIS since:
2019
Publisher:
Elsevier Inc.
All titles:
"Intermittent fasting beneficial effects on the steatosis and inflammation of the liver in mice fed a high-fat or a high-fructose diet"@eng
Other:
"Pre-press version"