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The National Agricultural Library is one of four national libraries of the United States, with locations in Beltsville, Maryland and Washington, D.C. It houses one of the world's largest and most accessible agricultural information collections and serves as the nexus for a national network of state land-grant and U.S. Department of Agriculture field libraries. In fiscal year 2011 (Oct 2010 through Sept 2011) NAL delivered more than 100 million direct customer service transactions.

Journal Article

Journal article

Neurochemical changes following high-dose aspartame with dietary carbohydrates. [letter]  [1983]

Wurtman, Richard J.;

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The results of pilot rodent studies with aspartame are discussed. It is suggested that its use as an artificial sweetener for soft drinks may cause human neurochemical changes that could have functional or behavioral consequences. The results show that, if aspartame-containing beverages are consumed with normal dietary carbohydrates, the effect of aspartame on brain composition is enhanced. Carbohydrates cause an insulin-mediated decrease in branched-chain amino acid levels that compete with phenylalanine and tyrosine across the blood-brain barrier. The results of 1 experiment showed that aspartame almost doubled rat brain phenylalanine levels, an effect which redoubled if carbohydrate also was consumed. The aspartame dose used in the study was consistent with the amount of aspartame an 8-year-old child might consume in soft drinks on a hot afternoon. (wz)

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Bibliographic information

Language:
English
Type:
Journal Article
In AGRIS since:
1984
Volume:
309
Issue:
7
Start Page:
429
End Page:
430
All titles:
" Neurochemical changes following high-dose aspartame with dietary carbohydrates. [letter] "
Other:
" charts. Includes 9 references "

From the journal

New England Journal of Medicine (USA)

ISSN : 0028-4793