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The National Agricultural Library is one of four national libraries of the United States, with locations in Beltsville, Maryland and Washington, D.C. It houses one of the world's largest and most accessible agricultural information collections and serves as the nexus for a national network of state land-grant and U.S. Department of Agriculture field libraries. In fiscal year 2011 (Oct 2010 through Sept 2011) NAL delivered more than 100 million direct customer service transactions.

Journal Article

Journal article

The thiourea insecticide/acaricide diafenthiuron has a novel mode of action: inhibition of mitochondrial respiration by its carbodiimide product  [1991]

Ruder, F.J. (Ciba-Geigy Ltd., Basel, Switzerland); Guyer, W.; Benson, J.A.; Kayser, H.;

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The thiourea diafenthiuron (CGA 106630) is a novel insecticide/acaricide. The present paper is concerned with the molecular mechanism underlying its action. So far, we have not found any direct target for diafenthiuron itself to explain its toxic effect. Since it is known that diafenthiuron is rapidly desulfurated abiotically to the pesticidal carbodiimide CGA 140408 in the presence of sunlight and singlet oxygen, CGA 140408 is probably the toxic agent mediating the in vivo action of diafenthiuron. Indeed, CGA 140,408 is one of the major in vivo products of diafenthiuron in Calliphora. Furthermore, there is evidence that cytochrome P450 mediates this desulfuration, biotically, since diaifenthiuron binds to cytochrome P450 as a substrate in rat liver microsomes. None of the known molecular targets of current commercial insecticides are affected by either diafenthiuron or CGA 140408 (e.g., acetylcholinesterase, sodium channel, acetylcholine receptor, chitin synthesis). Further, we cannot confirm a proposed octopaminergic action of CGA 140408. However, we have been able to demonstrate that CGA 140408, but not diafenthiuron, is a potent in vitro inhibitor of mitochondrial respiration in rat liver and Calliphora flight muscles. It selectively blocks the coupling site in a time-dependent manner which is different from the action of other pesticides. The resemblance in the chemical structure to the well-known mitochondrial inhibitor dicyclohexylcarbodiimide sugge
sts that CGA 140408 inhibits mitochondrial ATPase. Further experimental details are reported in a forthcoming paper

From the journal

Pesticide biochemistry and physiology (USA)

ISSN : 0048-3575