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The National Agricultural Library is one of four national libraries of the United States, with locations in Beltsville, Maryland and Washington, D.C. It houses one of the world's largest and most accessible agricultural information collections and serves as the nexus for a national network of state land-grant and U.S. Department of Agriculture field libraries. In fiscal year 2011 (Oct 2010 through Sept 2011) NAL delivered more than 100 million direct customer service transactions.

Journal Article

Journal article

Antitumor-promoting effects of gallotannins, ellagitannins, and flavonoids in mouse skin in vivo  [1994]

Perchellet, J.P. (Kansas State University, Manhattan, KS.); Gali, H.U.; Perchellet, E.M.; Laks, P.E.; et al.

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Hydrolyzable (HTs) and condensed tannins (CTs) were tested topically for their ability to inhibit the biochemical and biological effects of 12-O-tetradecanoylphorbol-13-acetate (TPA) in mouse epidermis in vivo. Overall, commercial tannic acid (TA), ellagic acid (EA), and n-propyl gallate (PG) inhibit the promotion of skin papillomas and carcinomas by TPA in relation with their ability to inhibit TPA-induced epidermal ornithine decarboxylase (ODC) activity, hydroperoxide (HPx) production, and DNA synthesis. Pure pentagalloylglucose, castalagin, vescalagin, catechin dialkyl ketals, and epicatechin-4-alkylsulphides or heterogenous sumac leaf TA, Aleppo gall TA, tara pod TA, loblolly pine bark CT, guamuchil bark CT, and southern red oak bark CT also inhibit these biochemical markers of TPA promotion to various degrees. When applied to initiated skin 20 min before each promotion treatment, the different TA samples all remarkably inhibit complete tumor promotion by TPA. Sumac leaf TA is the most effective. The antitumor-promoting activity of a TA pretreatment can be further enhanced by the application of TA 24 h after each promotion treatment with TPA. Commercial TA and Aleppo gall TA inhibit the second stage of tumor promotion by mezerein but not the first stage of tumor promotion by TPA. Therefore, tannins in general might be valuable to prevent and/or inhibit tumor propagation, the only reversible stage of tumorigenesis

From the journal

ACS symposium series (USA)

ISSN : 0097-6156