Written Paper

Biochemical profile indicative of insulin resistance in non-diabetic and diabetic cardiovascular patients  [2012]

Aslam, N. (University of Agriculture, Faisalabad (Pakistan). Dept. of Biochemistry) Sheikh, M.A. (University of Agriculture, Faisalabad (Pakistan). Dept. of Biochemistry) Khalil-ur-Rehman (University of Agriculture, Faisalabad (Pakistan). Dept. of Biochemistry) Nawaz, H. (University of Agriculture, Faisalabad (Pakistan). Inst. of Animal Nutrition and Feed Technology)

Access the full text

This study was aimed at assessment of some biochemical profiles associated with cardiovascular complications in non-diabetics and those suffering from diabetes type 2 in order to detect insulin resistance as an underlying cause. A total of 400 blood samples comprising of patients with (n=200) and without type 2 diabetes (n=200) were tested for different biochemical parameters following standard methods. The glycation, advanced glycosylation end products, glucose, insulin, C-peptide and LDL were lower in non-diabetic compared with diabetic subjects having a history of cardiovascular complaints. A positive correlation was found between the level of glycation and AGEs, glucose, HbA1c, C-peptide, cholesterol and LDL in nondiabetic and diabetic groups. There was, however, a negative correlation between the level of glycation and HDL in non-diabetic subjects with cardiovascular disease. Simultaneous presence of high levels of insulin, glucose and glycation suggested insulin resistance in diabetics as well as non-diabetics at risk of diabetes and associated cardiovascular complications. Therefore, disturbances in the biochemical profile and morbidity among all the groups of the present study were mainly attributed to insulin resistance. Diabetes and associated cardiovascular complications in the context of insulin resistance have been discussed.