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The National Agricultural Library is one of four national libraries of the United States, with locations in Beltsville, Maryland and Washington, D.C. It houses one of the world's largest and most accessible agricultural information collections and serves as the nexus for a national network of state land-grant and U.S. Department of Agriculture field libraries. In fiscal year 2011 (Oct 2010 through Sept 2011) NAL delivered more than 100 million direct customer service transactions.

Journal Article

Journal article

Anti-inflammatory effects of Terminalia phanerophlebia (Combretaceae) and identification of the active constituent principles  [2012]

Nair, J.J.; Aremu, A.O.; Van Staden, J.;

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The ‘Lebombo cluster leaf’ Terminalia phanerophlebia (Combretaceae) is used in traditional medicine in South Africa for a host of ailments, including aches and pain, wounds and infections, gynaecological conditions, inflammation, mental illness such as epilepsy, and sexually-transmitted diseases. Based on the anti-inflammatory activity (92.4% inhibition of the cyclooxygenase enzyme COX-2) initially observed for a crude extract, stems of T. phanerophlebia were here examined for the underlying phytochemical principles. Three cholestane triterpenoids β-sitosterol, β-sitostenone and stigmast-4-ene-3,6-dione were isolated from the ethanol extract by silica gel column chromatography via gradient elution with hexane/ethyl acetate mixtures. Structure elucidation was facilitated by use of physical and spectroscopic methods, including high field 2D NMR and mass spectroscopic techniques. The crude extract as well as β-sitosterol was seen to be selective inhibitors of the cyclooxygenase enzyme COX-2. This work is of chemosystematic relevance as it represents the first isolation of β-sitostenone and stigmast-4-ene-3,6-dione from any species of Terminalia.

Publicación

South African journal of botany

ISSN : 0254-6299