Written Paper

Effect of alpha-glucosylhesperidin on poor circulation in women  [2008]

Yoshitani, K.(Ezaki Glico Co. Ltd., Osaka (Japan)) Minami, T. Takumi, H. Kagami, Y. et al.

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Hesperidin is contained abundantly in citrus fruit and well known to have a strengthening effect on peripheral blood vessels. alpha-Glucosylhesperidin, produced from hesperidin by transglycosylation using cyclodextrin glucanotransferase, is known to be absorbed more effectively than hesperidin in humans. In this study, the effectiveness of alpha-glucosylhesperidin for treatment of blood circulation disorders in women was investigated. alpha-Glucosylhesperidin (250 mg/day) or placebo (powder sugar, 250 mg/day) was administered to 11 women (29.6+-3.9 years old) with coldness of the extremities using a double-blind placebo-controlled crossover protocol. Forty minutes after a single administration, and after 7 days of continuous administration, the hand of each subject was exposed to cooling stress at 15degC for 1 min, and then the skin surface temperature on the hand, blood flow, and the width of blood vessels in the finger were measured. In the case of single administration of alpha-glucosylhesperidin, the recovery rates of hand temperature and blood flow in the finger were significantly higher than those in the placebo group. In the case of continuous administration, the recovery rates of hand temperature and blood flow were also significantly higher than those in the placebo group. Therefore, it can be concluded that administration of alpha-glucosylhesperidin leads to an increase of peripheral blood flow, and thus recovery of skin surface temperature. In a
ddition, it was suggested that continuous administration of this compound maintains this effect and may alleviate poor circulation.