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The National Agricultural Library is one of four national libraries of the United States, with locations in Beltsville, Maryland and Washington, D.C. It houses one of the world's largest and most accessible agricultural information collections and serves as the nexus for a national network of state land-grant and U.S. Department of Agriculture field libraries. In fiscal year 2011 (Oct 2010 through Sept 2011) NAL delivered more than 100 million direct customer service transactions.

Actif (Le fournisseur de données a soumis des métadonnées au cours de la dernière année civile)
Journal Article

Article de revue

Screening species of Pilocarpus (Rutaceae) as sources of pilocarpine and other imidazole alkaloids  [2011]

Sawaya, Alexandra Christine Helena Frankland; Vaz, Boniek Gontijo; Eberlin, Marcos Nogueira; Mazzafera, Paulo;

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Plants of the Pilocarpus genus (Rutaceae) are popularly known as jaborandi and are the only source of pilocarpine, an imidazole alkaloid used in eye-drops for the treatment of glaucoma as well as for the stimulation of sweat and lachrymal glands. Alkaloid extracts from leaf samples of seven species of Pilocarpus, from the states of São Paulo and Maranhão in Brazil, were analyzed using HPLC-ESI-MS/MS. The samples contained between 0.88 ± 0.04 and 1.00 ± 0.14% of alkaloids in relation to the dry weight of their leaves, with significant differences in results (P ≤ 0.05) found only between Pilocarpus microphyllus planted in the state of Maranhão and Pilocarpus spicatus, Pilocarpus trachyllophus, Pilocarpus pennatifolius and Pilocarpus jaborandi; as well as between Pilocarpus spicatus and Pilocarpus racemosus. Pilocarpine was not found in P. spicatus, whereas in the other species it ranged from 2.6 ± 0.1 to 70.8 ± 1.2% of total alkaloids. P. microphyllus planted in the state of Maranhão for pilocarpine extraction had the highest total alkaloid content, but it had only 35% of pilocarpine in relation to total alkaloids. Three other species contained more pilocarpine in relation to total alkaloids: P. jaborandi (70.8%), P. racemosus (45.6%) and P. trachyllophus (38.7%); and could be candidates for pilocarpine extraction. Differences in alkaloid content were significant for all these samples (P ≤ 0.05). Imidazole alkaloids were observed and partially characterized
based on their retention times and high resolution mass. The seven species analyzed had different imidazole alkaloid profiles, but only one did not present quantifiable pilocarpine contents in its leaves. The Pilocarpus genus shows potential for the prospection of novel alkaloids.
(Revue
Genetic resources and crop evolution
ISSN : 0925-9864

Information bibliographique

Langue:
English
Type:
Journal Article
Sur AGRIS depuis:
2013
Volume:
58
Numéro:
3
Page initiale:
471
Page finale:
480
Editeur:
Dordrecht : Springer Netherlands
Tous les titres:
"Screening species of Pilocarpus (Rutaceae) as sources of pilocarpine and other imidazole alkaloids"@eng
Autre:
"Includes references"
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Information bibliographique

Langue:
English
Type:
Journal Article
Sur AGRIS depuis:
2013
Volume:
58
Numéro:
3
Page initiale:
471
Page finale:
480
Editeur:
Dordrecht : Springer Netherlands
Tous les titres:
"Screening species of Pilocarpus (Rutaceae) as sources of pilocarpine and other imidazole alkaloids"@eng
Autre:
"Includes references"