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Journal Article

Journal article

Ceramium boydenii, a Red Alga, Inhibits MDC/CCL22 Production Via Suppression of STAT1 Activation in HaCaT Keratinocyte  [2013]

Kang, N.J., Jeju National University, Jeju, Republic of Korea; Kang, K.J., Jeju National University School of Medicine, Jeju, Republic of Korea; Han, S.C., Jeju National University School of Medicine, Jeju, Republic of Korea; Hyun, E.A., Jeju National University School of Medicine, Jeju, Republic of Korea; et al.

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Ceramium boydenii belongs to euphorbia humitusa of red algae, and is distributed along the coast of Jeju island. This study was conducted to examine the anti-inflammatory effect and action mechanism of C. boydenii in the human keratinocyte cell line HaCaT. The 80% EtOH extract of C. boydenii inhibits the production of MDC (macrophage derived chemokine), an inflammatory chemokine, induced by IFN-γ and TNF-α in a concentration dependent manner. It also suppressed the phosphorylation and nuclear translocation of STAT1, a key transcription factor in IFN-γ and TNF-α signaling pathway, at the effective concentrations. These results suggest that C. boydenii demonstrates the anti-inflammatory activity via the suppression of STAT1 activation and has the significant value as an anti-inflammatory source.

学术期刊

Korean Journal of Pharmacognosy

ISSN : 0253-3073