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DOAJ is a community-curated online directory that indexes and provides access to high quality, open access, peer-reviewed journals. DOAJ is independent. All funding is via donations, 22% of which comes from sponsors and 78% from members and publisher members.

Background: Public health legal preparedness (PHLP) for emergencies is a core component of the health system response. However, the implementation of health legal preparedness differs between low- and middle-income countries (LMIC) and developed countries. Objective: This paper examines recent trends regarding public health legal preparedness for emergencies and discusses its role in the recen ...

SUBJECT: public aspects of medicine; emergency management; public health legal preparedness; emergency; ebola

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The inability of a dengue NS1 ELISA to detect Zika infections

Monique da Rocha Queiroz Lima et al. [2019-12]

Abstract The presence of dengue virus (DENV), Zika virus (ZIKV) and Chikungunya virus (CHIKV) in Brazil, may result in a difficult diagnosis due to the signs and symptoms shared by those. Moreover, as DENV and ZIKV belong to the same family, serological assays may show a high rate of cross-reactivity. Here, we evaluated a Dengue NS1 capture assay for early and differential diagnosis of dengue ...

SUBJECT: medicine; science; zika

We queried hospital patients about international travel in the previous 30 days to assess potential importation of emerging infections. We used 12 months of deidentified data to analyze patient demographics, travel destinations, and diagnoses for exposure to Zika virus. Our approach could be used to analyze potential infectious disease exposures.

SUBJECT: medicine; screening; travel health; pregnancy; reproductive age

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Introduction. The article considers the problems of metrological support of catalytic activity measurements. The paper gives certain characteristics of the State Primary Special Measurement Standard for the unit of catalytic activity – KATAL and examines the role of reference materials (RMs) in ensuring the metrological traceability of measurement results.Materials and methods. A method for me ...

SUBJECT: catalytic concentration; calibration hierarchies; technology; metrological traceability; state primary measurement standard katal

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Lassa viral hemorrhagic fever

Viroj Wiwanitkit [2020-]

SUBJECT: medicine; hemorrhagic fever

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The immunopathogenesis of Zika virus: an overview

Javanian Mostafa et al. [2018-06]

SUBJECT: internal medicine; zika

This article discusses some of the tensions caused by the friction between distinct temporal regimes associated with an epidemic episode. This text is based on the study of the way information related to the Zika epidemic and microcephaly in Brazil was speeded out during the year 2015-2016. Starting with the context of intense mediatization, as well as of the complex temporality produced by di ...

SUBJECT: mediatization; risk; zika virus; time; zika

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Granzyme A in Chikungunya and Other Arboviral Infections

Alessandra S. Schanoski et al. [2020-01]

Granzyme A (GzmA) is secreted by cytotoxic lymphocytes and has traditionally been viewed as a mediator of cell death. However, a growing body of data suggests the physiological role of GzmA is promotion of inflammation. Here, we show that GzmA is significantly elevated in the sera of chikungunya virus (CHIKV) patients and that GzmA levels correlated with viral loads and disease scores in these ...

SUBJECT: granzyme a; arthritis; nk cell; immunologic diseases. allergy; zika

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The development of effective vaccines continues to be a key goal for public health bodies, governments, funding bodies and pharmaceutical companies. With new vaccines such as Shingrix targeting Shingles and Bexsero for Meningitis B, licensed in recent years, today s population can be protected from more infectious diseases than ever before. Despite this, we are yet to license vaccines for some ...

SUBJECT: clinical trial; medicine; vaccine; memory; t-cell

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We present two probabilistic models to estimate the risk of introducing infectious diseases into previously unaffected countries/regions by infective travellers. We analyse two distinct situations, one dealing with a directly transmitted infection (measles in Italy in 2017) and one dealing with a vector-borne infection (Zika virus in Rio de Janeiro, which may happen in the future). To calculat ...

SUBJECT: zika; computer applications to medicine. medical informatics

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