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The National Agricultural Library is one of four national libraries of the United States, with locations in Beltsville, Maryland and Washington, D.C. It houses one of the world's largest and most accessible agricultural information collections and serves as the nexus for a national network of state land-grant and U.S. Department of Agriculture field libraries. In fiscal year 2011 (Oct 2010 through Sept 2011) NAL delivered more than 100 million direct customer service transactions.

Bone marrow (BM)-derived T-cell progenitors differentiate into CD4 or CD8 single-positive (SP) cells in the thymus. We have previously reported that a single autosomal mutation, thid, causes a defect in the maturation of CD4 SP thymocytes and an abnormality of peripheral helper T cells in the LEC rat. In this study we attempted to identify a gene responsible for the thid mutation. We first per ...

POSTED TO: Mammalian genome official journal of the International Mammalian Genome Society [0938-8990]

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We analyzed TAF1/DYT3, a complex transcript system that is composed of at least 43 exons. Thirty-eight exons code for TATA box binding protein associated factor I (TAF1). Five downstream exons (d1-d5) of yet unknown function can either form transcripts with TAF1 exons or be transcribed independently. Splice variants can include d (notably d3 and d4) plus at least 12 TAF1 exons (exons 26-37 but ...

POSTED TO: Mammalian genome official journal of the International Mammalian Genome Society [0938-8990]

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Septins are a highly conserved family of GTP-binding cytoskeletal proteins implicated in multiple cellular functions, including membrane transport, apoptosis, cell polarity, cell cycle regulation, cytokinesis, and oncogenesis. Here we describe the characterization of a novel interacting partner of the septin family, initially cloned from a human testis expression library following yeast two-hy ...

POSTED TO: Mammalian genome official journal of the International Mammalian Genome Society [0938-8990]

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Bulldog dwarfism in Dexter cattle is one of the earliest single-locus disorders described in animals. Affected fetuses display extreme disproportionate dwarfism, reflecting abnormal cartilage development (chondrodysplasia). Typically, they die around the seventh month of gestation, precipitating a natural abortion. Heterozygotes show a milder form of dwarfism, most noticeably having shorter le ...

POSTED TO: Mammalian genome official journal of the International Mammalian Genome Society [0938-8990]

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Depending on the amount of alimentary proteins, between 6 and 18 g nitrogenous material per day enter the large intestine lumen through the ileocaecal junction. This material is used as substrates by the flora resulting eventually in the presence of a complex mixture of metabolites including ammonia, hydrogen sulfide, short and branched-chain fatty acids, amines; phenolic, indolic and N-nitros ...

SUBJECT: adaptative metabolism; bacterial metabolites; colon epithelium; amino acids

POSTED TO: Amino acids [0939-4451]

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Gliotransmission is a process in which astrocytes are dynamic elements that influence synaptic transmission and synaptogenesis. The best-known gliotransmitters are glutamate and ATP. However, in the past decade, it has been demonstrated that D-serine, a D-amino acid, acts as a gliotransmitter in glutamatergic synapses. The physiological relevance of D-serine is sustained by the way in which it ...

SUBJECT: d-serine; nmda; gliotransmission; glutamate; glycine site

POSTED TO: Amino acids [0939-4451]

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Tuberous sclerosis (TSC) is an autosomal dominantly inherited disease affecting 1 in 6000 individuals. The TSC gene products, hamartin and tuberin, form a complex, of which tuberin is assumed to be the functional component being involved in a wide variety of different cellular processes. Tuberin has been demonstrated to be localized to both, the cytoplasm and the nucleus. The cytoplasmic/nucle ...

SUBJECT: cytoplasm; nucleus; p27; tuberin; localization

POSTED TO: Amino acids [0939-4451]

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The aim of the present study was to measure MPO activity in PMN leukocytes after endotoxin administration, and to compare the levels of NO₂ - competing with taurine for reaction with HOCl. Furthermore we aimed to determine TauCl levels, a product of MPO-H₂O₂-Halide system, and to evaluate anti-inflammatory properties of PMN in endotoxemia. In addition, our second objective was to investigate t ...

SUBJECT: nitric oxide; myeloperoxidase; taurine; polymorphonuclear leukocyte

POSTED TO: Amino acids [0939-4451]

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Amino acids are widely used in biotechnology applications. Since amino acids are natural compounds, they can be safely used in pharmaceutical applications, e.g., as a solvent additive for protein purification and as an excipient for protein formulations. At high concentrations, certain amino acids are found to raise intra-cellular osmotic pressure and adjust to the high salt concentrations of ...

SUBJECT: freeze drying; protein purification; formulation; osmolyte; aggregation suppression

POSTED TO: Amino acids [0939-4451]

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In maize seedlings, chilling causes a reduction of glutamine synthetase (GS) activity, while acclimation protects GS (manuscript submitted). Since ROS can oxidize both protein-bound and free Met to methionine sulfoxide (MSO) and further to methionine sulfone (MSO2, a GS inhibitor), it was hypothesized that the chilling-induced oxidative stress may cause accumulation of MSO and MSO2, thus contr ...

SUBJECT: methionine oxides; n-transporting amino acids; acclimation; cooling; pmsr

POSTED TO: Amino acids [0939-4451]

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