Effect of Testosterone and cyclic AMP-theophylline on ultrastructure and several enzyme's activities in rat epididymis
1988
Cheong, K.S. | Choe, R.S. (Yonsei Univ., Seoul (Korea R.). Coll. of Science)
This study was made to investigate the effect of testostrone and cyclic-AMP (cAMP) on rat epididymis. Peritoneal injections of testosterone and cAMP to rats were carried out. The activities of acid phosphatase (ACP), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) were measured and ultrastructural changes of luminal eqithelial cells were observed. As a result, the activity of ACP was significantly decreased on the third day, that of ALP on the fifth day and that of LDH on the seventh day respectively in castrated group. In addition, the activities of ACP and ALP were significantly increased when treated with testosterone for 5 days, that of LDH when treated with testosterone for 7 days. In case of cAMP and cAMP- theophylline injection, the activities of ACP and LDH were increased but the range of increase was of no sidgnificance. However a significant increase in the activity of ALP was seen on both cases. On electron microscopic examination, gradually deformed Golgi complex, destructed mitochondria and disrupted stereocilia were observed in castrated group. In case of testosterone injection, disrupted Golgi complex, mitochondria and stereocilia showed recovery. When cAMP and cAMP-theophylline were injected as an alternative, various cytoplasmic organelles as well as Golgi complex were recovered but sterocilia remained unrecovered
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