Introduction of several groups to the D-ring of grayanotoxin
1992
Iwasa, J. (Okayama Univ. (Japan). Faculty of Agriculture) | Kawanishi, T. | Handa, S. | Kamano, H. | Yamamoto, S. | Okamoto, M. | Takeda, N. | Nakamura, M. | Masutani, T. | Shiro, M. | Nakajima, S. | Baba, N. | Seyama, I.
Grayanotoxin (GTX), one of the lipid-soluble Na+ channel openers, contains four rings (A, B, C and D) and the chemical groups essential for the pharmacological action are located on the A- and B-rings. To study the biological significance of functional groups on the D-ring, 51 new derivatives were prepared from alpha-dihydro GTX-II. These new compounds and the previously prepared GTXs were directly applied to the intracellular phase of internally perfused squid giant axons
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