Clinical studies on serum cholinesterase in domestic animals, 11: Studies on the change in the serum total activity and fraction of isoenzyme in cholinesterase occasioned by drug administration and surgical operation
1991
Morizono, M. (Kagoshima Univ. (Japan). Faculty of Agriculture) | Iwatsuki, T. | Akuzawa, M.
This study revealed the changes of total activities and isoenzyme activities in serum cholinesterase (S-ChE) in dogs occasioned by the experimental operations. 1) Total activity decreased with the peroral administration of relatively low toxic organophosphate drugs. Activities of all the fractions in the isoenzyme decreased, and the rate was significant in fractions mobilizing faster than others. The decrease of activity seemed to be unrelated to the presence of adverse reactions, such as salivation and vomiting. 2) In the cases of bile duct ligated experimentally, total activity changed without consistent tendency, and the activity of C2 fraction of isoenzyme, fast in mobility, showed a significant increase in all the cases. 3) In the cases of diabetes mellitus induced experimentally by alloxan, total activities increased within a small extent comparing with those of preadministration; and in the activity of isoenzyme, fractions of C1, C2 and C3, fast in mobility, as well as those of C6 and C7, slow in mobility, showed high activities, on the other hand, those of C4 and C5, moderate in mobility, showed no consistent tendency in the activity-change. 4) In the cases of experimental pancreatectomy, total activity increased slightly higher than that of the preoperation. Isoenzyme pattern tended to resemble that of hepatic dysfunction. 5) From the results of the above third and forth experiments, S-ChE was ascertained to have no direct relationship with ChE in the pancreas of dogs, which was fixed to be specifically higher than that in any other organs
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