Levels of lipid peroxidation in selected population groups
1994
Krajcovicova-Kudlackova, M. | Babinska, K. | Simoncic, R. | Bederova, A. (Vyskumny Ustav Vyzivy, Bratislava (Slovakia))
The levels of conjugated dienes of fatty acids, which are the 1st product of lipid peroxidation, were estimated in vegetarians aged 18 to 39 years and compared to corresponding values of a non-vegetarian group of the same age. A similar comparison was performed between groups of probands from Dolny Kubin, Slovkia, an area with low incidence of colorectal tumours, and Bratislava, where the incidence of this disease is very high. Nutritional conditions in terms of lipid intake were evaluated by dietetic questionnaires and by estimation of plasma cholesterol levels. The values of lipid peroxidation were correlated with vitamin C content which participates as an antioxidant in the neutralization of free oxygen radicals. Increased amounts of conjugated dienes were found in the plasma of vegetarians. Both the dietetic survey and low cholesterol levels (significant as compared to non-vegetarians) indicated a predominant intake of vegetable fats (and thus of unsaturated fatty acids). In addition, low levels of vitamin C in leucocytes were found in this group. Vitamin C content in non-vegetarians was above the lower limit of the physiological range. This can explain the reduced levels of conjugated dienes as well. The levels of lipid peroxidation in the group from Dolny Kubin were significantly lower than those from Bratislava. Higher lipid peroxidation in the group from Bratislava did not correlate with physiological levels of vitamin C in this group. Values in the group from Dolny Kubin were significantly lower, particularly in males they were well below 39.7 micromol.l** (-1). A polluted environment in a large industrialized city like Bratislava probably significantly contributes to this effect. One of the conclusions is the necessity to study the mechanisms of detoxication of reactive oxygen species.
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