Dynamics in serum enzymes activities in experimental and bovine fascioliasis
1990
Yoshio Kimura | Mitsuo Satoh | Masato Takahashi (Prefecture of Tochigi, Tochigi (Japan). Livestock Sanitary Laboratory)
6 enzymes (glutamic oxaloacetic transaminase (GOT). glutamate dehydrogenase (GLDH), gamma glutamyltransferase (GGT), isocitrate dehydrogenase (ICDH), alkaline phosphatase (ALP), lactate dehydrogenase (LDH)) were assayed by using commercial kit in experimentally infecting calves and 4 enzymes (GDT, GLDH, GGT, ornithine carbamyltransferase (OCT) were assayed in naturally infecting cows. Egg per gram (EPG) was also mesured by breeds method in experimental and natural groups. Eggs of Fasciola sp. were excreted in feces at the 12th week after dosing of MC in No.3 and at the 16th week in No.1 and at the 15th week in No.2 EPG of No.3 was the highest and that of No.2 was inclined to be higher than that of No.1. Activities of GGT, GLDH and ICDH in all cases increased markedly between the 6th and 12th week after infection and after the 15th week began to decrease. The peak activities of those enzymes depended on number of EPG in individual calves. Activities of GLDH an GGT increased more sharply than the other enzymes. The number of mature flukes in liver were 32 in No. 1, 57 in No.2 and 206 in No.3. In naturally infecting cows EPG became negative in 83.3 % of group A and 92.3 % of group B after the 2 nd week after treatment. In that time, individual enzyme activity decreased significantly. GLDH, GGT and OCT decreased more sharply than GOT. No noticeable changes were observed in EPG and serum enzymes in group C. GLDH and GGT were the most sensitive indicators of liver dysfunction caused by bovine fascoliasis. Additionally OCT was also sensitive indicator from the results of natural cases. Moreover tricrabendazole was proved to be a practical anthelmentic against Fasciola sp.
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