Screening for anti tumor-promoters in vegetable-juices
1997
Ogino, H. (Kagome Co. Ltd., Nishinasuno, Tochigi (Japan). Research Inst.) | Sakamoto, H. | Ishiguro, Y.
In order to search for tumor-preventive substances in vegetables, we screened 32 samples of vegetable extracts for activity to suppress the inhibitory effect of okadaic acid (OA) on protein phosphatase-2A (PP2A), since Oa promotes tumor formation by inhibiting this enzyme. Soluble factions in vegetable juices were obtained by hexane, butanol, and water extraction and tested separately for their effects in inhibiting the activity of OA on PP2A (anti-OA activity). The butanol-soluble fractions obtained respectively from carrot, garlic, parsley, red bell pepper and spinach showed significant anti-OA activity. The butanol-soluble fractions from leek and tomato, and the aqueous fractions from asparagus, carrot, parsley and spinach also showed mild anti-OA activity. Weak anti-OA activity was observed in water-soluble extracts of broccoli and tomato. The anti-OA activity of the vegetables we rested fluctuated significantly among various cultivars, even within the same species. Although the principal agents have not yet been clarified, the present results strongly suggest the presence of substances that suppress OA activity
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