Ultrastructural and morphometric analysis of rat brown adipocytes after short-term sucrose consumption

Cakic-Milosevic, M. . Faculty of Biology, Institute of Zoology; Koko, V.; Davidovic, V.; Radovanovic, J.

Ultrastructural and morphometric analysis of rat brown adipocytes after short-term sucrose consumption

1997

Cakic-Milosevic, M. (University of Belgrade, Belgrade (Yugoslavia). Faculty of Biology, Institute of Zoology) | Koko, V. | Davidovic, V. | Radovanovic, J.

The study of rat brown adipocytes was carried out after short-term sucrose consumption since it is known that sucrose overfeeding stimulates brown adipose tissue metabolic activity.The results showed that the cell and nucleus profile areas as well as nucleus volume density were increased in sucrose-treated rats. Lipid droplet volume density remained unchanged, whereas cytoplasm volume density was increased. The number of mitochondria was significantly increased, their cristae being more numerous, and the volume density of mitochondrial matrix reduced as compared with the control. Ultrastructural examination revealed that the fine internal structure of the cell, particularly that of mitochondria, was also affected by sucrose treatment. The results demonstrate the mode of altering the ultrastructure of rat brown adipocytes accompanying a sucrose-rich diet. They indicate that there are no significant differences, at the level of cell morphology, between diet-induced and thermoregulatory thermogenesis, previously widely explored by other authors.

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