Effect of inulin on nutritional hypercholesterolemia and chemically induced precancerous lesions on rat colon
2000
Bobek, P. (Ustav Preventivnej a Klinickej Mediciny, Bratislava (Slovak Republic)) | Galbavy, S. | Mariassyova, M.
The influence of the diet supplemented by 15% of inulin on the nutritionally induced hypercholesterolemia and colon carcinogenesis induced by dimethylhydrazine (DMH) was examined in just weaned male Wistar rats fed diet containing 0.3% cholesterol. DMH was added subcutaneously in a dosis of 20 mg/kg body weight once a week during a three-weeks period. Five weeks after the last DMH application, the animals were sacrified 18 h after food removal. Inulin in the diet did not influence (in comparison with the control cellulose-free diet or the control diet with 15% cellulose) either the serum cholesterol and triacylglycerol level or the content of cholesterol in the liver. The inulin-containing diet (and also the control diet with 15% of cellulose) significantly - nearly to 50% - lowered the content of conjugated dienes in colon. In comparison with both control diets, the animals fed the inulin diet had significantly - more than by 30% - lowered activity of superoxide dismutase and oppositely, the glutathione-S-transferase activity was in a similar range significantly increased. Neither the diet with inulin, nor the diet with 15% cellulose, significantly influenced (in comparison with the cellulose-free diet) the incidence or the character of precancerous lesions, aberrant crypt foci, on colon. In the inulin-fed group, by 30% less animals died in the course of the experiment (in comparison with both control groups)
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