Regulation of body temperature to high environmental temperature by far-infrared radiation in female mice
1998
Nagasawa, H. (Meiji Univ., Kawasaki, Kanagawa (Japan). Faculty of Agriculture) | Udagawa, Y.
For the biomedical research on far-infrared radiated hyperthermic therapy of cancer, high body temperature was produced through exposure to that of the environment in a high mammary tumour strain of female SHN mice. In Experiment I, the mice were placed in a high temperature room at 48 degree C. Body temperature could no longer be regulated and increased linearly. At body temperature higher than 42 degree C, the experiment was terminated and the mice were moved immediately to a room maintained at 24 degree C. Six out of 11 mice (54.5%) died in one day thereafter. In Experiment two, the mice were placed in a hot room since the room temperature started to be elevated. The experiment was stopped when body temperature reached 40-43 degree C. Body temperature was not regulated at the room temperature higher than 30 degree C, but no mice died after the experiment. In Experiment thee, exposure to high temperature was repeated three times every 2 days under the same condition as in Experiment two. Body weight, which decreased about 3% just after each experiment, recovered the next morning and the mice showed no deleterious effects. In all cases, the mice could not regulate the body temperature higher than 30 degree C and elevation of body temperature to more than 42 degree C induced death. Meanwhile, the placement of mice in the hot room since the room temperature was not high showed little side-effect and the repeated exposure to the high temperature requisite in the hyperthermic therapy of cancer could be tolerated. Energy from far-infrared rays is absorbed and converted to the thermal energy in subcutaneous tissue. Thus, in addition to the high temperature in the hot room, thermal energy from the far-infrared rays themselves would also contribute to the elevation of body temperature
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