Antifungal activity of medium-chain saturated fatty acids and their inhibitory activity to the plasma membrane H+-ATPase of fungi
1999
Lee, S.H. | Kim, C.J. (Korea Research institute of Bioscience and Biotechnology, Taejon (Korea Republic).)
In order to know the antifungal characteristics of saturated fatty acids having 6 to 12 carbons, their minimum inhibitory concentrations (MICs) and minimum fungicidal concentrations(MFCs) were estimated against Saccharomyces cerevisiae. Fatty acids from C6 to C11 exhibited increasing activity with chain length, but C12 fatty acid did not show activity at all. In relation to antifungal modes of actions, fatty acids investigated showed on inhibitory activity toward the plasma membrane H+-ATPase of Saccharmyces cerevisiae. Their inhibitions to theglucose-induced acidification and ATP hydrolysis caused by the proton pump were found to be in common with antifungal activities. At the test concentration of 1 mM, hexanoic cid (C6) showed the lowest inhibition of about 30%, while undecanoic acid(C11) showed the strongest inhibition of over 90%. In addition, as seen with antifungal activity, the inhibitory activity of dodecanoic acid (C12) was suddenly reduced to less than 50%.
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