Optimum time interval between the first vaccination and the booster of sheep for Clostridium perfringens type D
Bernath, S.(Institute for Veterinary Medicinal Products (Hungary))E-mail:bernath@oai.hu | Fabian, K.(Institute for Veterinary Medicinal Products (Hungary)) | Kadar, I.(Institute for Veterinary Medicinal Products (Hungary)) | Szita, G.(Szent Istvan Univ., Budapest (Hungary). Dept. of Food Hygiene) | Barna, T.(Institute for Veterinary Medicinal Products (Hungary))
The goal of the present study was to determine the optimum time interval between the first and the second vaccination of sheep against Clostridium perfringens type D with aluminium hydroxide-adjuvanted monovalent vaccine. Eight weeks after the first vaccination of 13 sheep aged 6 months, 12 animals developed a higher and 1 animal a lower antibody titre than 0.1 IU/mL, which is protective under natural conditions. No correlation was found between the extent of the immune response and the length of the period between the immunizations in 24 sheep vaccinated twice at an interval of 2, 4, or 8 weeks. In spite of this, revaccination is suggested 8 weeks after the first immunization, because in this case most of the animals are protected continuously up to the time of the second vaccination, and the second antibody peak develops later. This vaccination schedule provides protective immune response for the longest period of time.
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